Ontology highlight
ABSTRACT:
SUBMITTER: Mozhdehi D
PROVIDER: S-EPMC6693588 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Mozhdehi Davoud D Luginbuhl Kelli M KM Dzuricky Michael M Costa Simone A SA Xiong Sinan S Huang Fred C FC Lewis Mae M MM Zelenetz Stephanie R SR Colby Christian D CD Chilkoti Ashutosh A
Journal of the American Chemical Society 20190104 2
Biological systems use post-translational modifications (PTMs) to control the structure, location, and function of proteins after expression. Despite the ubiquity of PTMs in biology, their use to create genetically encoded recombinant biomaterials is limited. We have utilized a natural lipidation PTM (hedgehog-mediated cholesterol modification of proteins) to create a class of hybrid biomaterials called cholesterol-modified polypeptides (CHaMPs) that exhibit programmable self-assembly at the nan ...[more]