Ontology highlight
ABSTRACT:
SUBMITTER: Gbenedio OM
PROVIDER: S-EPMC6693836 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Gbenedio Oghenekevwe M OM Bonnans Caroline C Grun Delphine D Wang Chih-Yang CY Hatch Ace J AJ Mahoney Michelle R MR Barras David D Matli Mary M Miao Yi Y Garcia K Christopher KC Tejpar Sabine S Delorenzi Mauro M Venook Alan P AP Nixon Andrew B AB Warren Robert S RS Roose Jeroen P JP Depeille Philippe P
JCI insight 20190625
Colorectal cancer (CRC) is the third most frequent neoplastic disorder and is a main cause of tumor-related mortality as many patients progress to stage IV metastatic CRC. Standard care consists of combination chemotherapy (FOLFIRI or FOLFOX). Patients with WT KRAS typing are eligible to receive anti-EGFR therapy combined with chemotherapy. Unfortunately, predicting efficacy of CRC anti-EGFR therapy has remained challenging. Here we uncover that the EGFR-pathway component RasGRP1 acts as CRC tum ...[more]