Ontology highlight
ABSTRACT:
SUBMITTER: Parker MM
PROVIDER: S-EPMC6693893 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Parker Margaret M MM Hao Yuan Y Guo Feng F Pham Betty B Chase Robert R Platig John J Cho Michael H MH Hersh Craig P CP Thannickal Victor J VJ Crapo James J Washko George G Randell Scott H SH Silverman Edwin K EK San José Estépar Raúl R Zhou Xiaobo X Castaldi Peter J PJ
eLife 20190725
Murine studies have linked TGF-β signaling to emphysema, and human genome-wide association studies (GWAS) studies of lung function and COPD have identified associated regions near genes in the TGF-β superfamily. However, the functional regulatory mechanisms at these loci have not been identified. We performed the largest GWAS of emphysema patterns to date, identifying 10 GWAS loci including an association peak spanning a 200 kb region downstream from <i>TGFB2</i>. Integrative analysis of publicl ...[more]