Ontology highlight
ABSTRACT:
SUBMITTER: Xie M
PROVIDER: S-EPMC6693908 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Xie Mouzhe M Yu Lei L Bruschweiler-Li Lei L Xiang Xinyao X Hansen Alexandar L AL Brüschweiler Rafael R
Science advances 20190814 8
Protein function depends critically on intrinsic internal dynamics, which is manifested in distinct ways, such as loop motions that regulate protein recognition and catalysis. Under physiological conditions, dynamic processes occur on a wide range of time scales from subpicoseconds to seconds. Commonly used NMR spin relaxation in solution provides valuable information on very fast and slow motions but is insensitive to the intermediate nanosecond to microsecond range that exceeds the protein tum ...[more]