Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC6693916 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Science advances 20190814 8
Genotype-by-environment interaction (GEI) is a fundamental component in understanding complex trait variation. However, it remains challenging to identify genetic variants with GEI effects in humans largely because of the small effect sizes and the difficulty of monitoring environmental fluctuations. Here, we demonstrate that GEI can be inferred from genetic variants associated with phenotypic variability in a large sample without the need of measuring environmental factors. We performed a genom ...[more]