Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC6693916 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Wang Huanwei H Zhang Futao F Zeng Jian J Wu Yang Y Kemper Kathryn E KE Xue Angli A Zhang Min M Powell Joseph E JE Goddard Michael E ME Wray Naomi R NR Visscher Peter M PM McRae Allan F AF Yang Jian J
Science advances 20190814 8
Genotype-by-environment interaction (GEI) is a fundamental component in understanding complex trait variation. However, it remains challenging to identify genetic variants with GEI effects in humans largely because of the small effect sizes and the difficulty of monitoring environmental fluctuations. Here, we demonstrate that GEI can be inferred from genetic variants associated with phenotypic variability in a large sample without the need of measuring environmental factors. We performed a genom ...[more]