Ontology highlight
ABSTRACT:
SUBMITTER: Szpila M
PROVIDER: S-EPMC6694115 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Szpila Marcin M Walewska Agnieszka A Sabat-Pośpiech Dorota D Strączyńska Patrycja P Ishikawa Takao T Milewski Robert R Szczepańska Katarzyna K Ajduk Anna A
Scientific reports 20190814 1
Postovulatory ageing of mammalian oocytes occurs between their ovulation and fertilization and has been shown to decrease their developmental capabilities. Aged oocytes display numerous abnormalities, including altered Ca<sup>2+</sup> signalling. Fertilization-induced Ca<sup>2+</sup> oscillations are essential for activation of the embryonic development, therefore maintaining proper Ca<sup>2+</sup> homeostasis is crucial for the oocyte quality. In the present paper, we show that the mechanism un ...[more]