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Resveratrol delays postovulatory aging of mouse oocytes through activating mitophagy.


ABSTRACT: Resveratrol (3,5,4'-trihydroxystilbene, RSV) is a natural potential anti-aging polyphenolic compound frequently used as a nutritional supplement against several diseases. However, the underlying mechanisms by which resveratrol regulates postovulatory aging of oocytes are still insufficiently known. In this study, we found that resveratrol could delay postovulatory aging and improve developmental competence of oocytes through activating selective mitophagy in the mouse. Resveratrol could maintain spindle morphology but it disturbed cortical granule (CG) distribution during oocyte aging. This might be due to upregulated mitophagy, since blocking mitophagy by cyclosporin A (CsA) treatment affected oocyte quality by damaging mitochondrial function and it decreased embryonic development. In addition, we also observed an involvement of FoxO3a in regulating mitophagy in aging oocytes following resveratrol treatment. Taken together, our results provide evidence that mitophagy induced by resveratrol is a potential mechanism to protect against postovulatory oocyte aging.

SUBMITTER: Zhou J 

PROVIDER: S-EPMC6932885 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Resveratrol delays postovulatory aging of mouse oocytes through activating mitophagy.

Zhou Jilong J   Xue Zhouyiyuan Z   He Hai-Nan HN   Liu Xin X   Yin Shu-Yuan SY   Wu Dan-Ya DY   Zhang Xia X   Schatten Heide H   Miao Yi-Liang YL  

Aging 20191213 23


Resveratrol (3,5,4'-trihydroxystilbene, RSV) is a natural potential anti-aging polyphenolic compound frequently used as a nutritional supplement against several diseases. However, the underlying mechanisms by which resveratrol regulates postovulatory aging of oocytes are still insufficiently known. In this study, we found that resveratrol could delay postovulatory aging and improve developmental competence of oocytes through activating selective mitophagy in the mouse. Resveratrol could maintain  ...[more]

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