Insights on the Role of Putative Muscle-Derived Factors on Pancreatic Beta Cell Function.
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ABSTRACT:
SUBMITTER: Mizgier ML
PROVIDER: S-EPMC6694406 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
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Insights on the Role of Putative Muscle-Derived Factors on Pancreatic Beta Cell Function.
Mizgier Maria L ML Fernández-Verdejo Rodrigo R Cherfan Julien J Pinget Michel M Bouzakri Karim K Galgani Jose E JE
Frontiers in physiology 20190808
Skeletal muscle is a main target of insulin action that plays a pivotal role in postprandial glucose disposal. Importantly, skeletal muscle insulin sensitivity relates inversely with pancreatic insulin secretion, which prompted the hypothesis of the existence of a skeletal muscle-pancreas crosstalk mediated through an endocrine factor. The observation that changes in skeletal muscle glucose metabolism are accompanied by altered insulin secretion supports this hypothesis. Meanwhile, a muscle-deri ...[more]
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