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Four New Pterosins from Pteris cretica and Their Cytotoxic Activities.

ABSTRACT: Phytochemical investigation of the aerial parts of Pteris cretica led to the isolation and elucidation of nine pterosins, including four new pterosins, creticolacton A (1), 13-hydroxy-2(R),3(R)-pterosin L (2), creticoside A (3), and spelosin 3-O-?-d-glucopyranoside (4), together with five known pterosins 5-9. Their structures were identified mainly on the basis of 1D and 2D NMR spectral data, ESI-MS and literature comparisons. Compounds 1 and 3 were new type of petrosins with a six membered ring between C-14 and C-15. The new compounds were tested in vitro for their cytotoxic activities against four human tumor cell lines (SH-SY5Y, SGC-7901, HCT-116, Lovo). Results showed that compounds 1 and 2 exhibited cytotoxic activity against HCT-116 cells with IC₅₀ value of 22.4 ?M and 15.8 ?M, respectively.

SUBMITTER: Lu J

PROVIDER: S-EPMC6696042 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Four New Pterosins from Pteris cretica and Their Cytotoxic Activities.

Lu Jian J Peng Caiying C Cheng Shuang S Liu Jianqun J Ma Qinge Q Shu Jicheng J

Molecules (Basel, Switzerland) 20190730 15

Phytochemical investigation of the aerial parts of Pteris cretica led to the isolation and elucidation of nine pterosins, including four new pterosins, creticolacton A (1), 13-hydroxy-2(R),3(R)-pterosin L (2), creticoside A (3), and spelosin 3-O-β-d-glucopyranoside (4), together with five known pterosins 5-9. Their structures were identified mainly on the basis of 1D and 2D NMR spectral data, ESI-MS and literature comparisons. ...[more]

PMID: 31366093

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Project description:BACKGROUND:Arsenic toxicity induces a range of metabolic responses in plants, including DNA methylation. The focus of this paper was on the relationship between As-induced stress and plant senescence in the hyperaccumulator Pteris cretica var. Albo-lineata (Pc-Al). We assume difference in physiological parameters and level of DNA methylation in young and old fronds as symptoms of As toxicity. RESULTS:The As accumulation of Pc-Al fronds, grown in pots of haplic chernozem contaminated with 100?mg As kg-?1 for 122?days, decreased with age. Content of As was higher in young than old fronds for variants with 100?mg As kg-?1 (2800 and 2000?mg As kg-?1 dry matter, respectively). The highest As content was determined in old fronds of Pc-Al grown in pots with 250?mg As kg-?1. The increase with age was confirmed for determined nutrients - Cu, Mg, Mn, S and Zn. A significant elevation of all analysed nutrients was showed in old fronds. Arsenic accumulation affected DNA methylation status in fronds, but content of 5-methylcytosine (5mC) decreased only in old fronds of Pc-Al (from 25 to 12%). Determined photosynthetic processes showed a decrease of fluorescence, photosynthetic rate and chlorophylls of As treatments in young and old fronds. Water potential was decreased by As in both fronds. Thinning of the sclerenchymatous inner cortex and a reduction in average tracheid metaxylem in the vascular cylinder was showed in roots of As treatment. Irrespective to fronds age, physiological parameters positively correlated with a 5mC while negatively with direct As toxicity. Opposite results were found for contents of Cu, Mg, Mn, S and Zn. CONCLUSIONS:The results of this paper point to changes in the metabolism of the hyperaccumulator plant Pc-Al, upon low and high exposure to As contamination. The significant impact of As on DNA methylation was found in old fronds. Irrespective to fronds age, significant correlations were confirmed for 5mC and As toxicity. Our analysis of the very low water potential values and lignification of cell walls in roots showed that transports of assimilated metabolites and water between roots and fronds were reduced. As was showed by our results, epigenetic changes could affect studied parameters of the As hyperaccumulator plant Pc-Al, especially in old fronds.

Dataset Information

Four New Pterosins from Pteris cretica and Their Cytotoxic Activities.

Publications

Four New Pterosins from <i>Pteris cretica</i> and Their Cytotoxic Activities.

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