Ontology highlight
ABSTRACT:
SUBMITTER: Zeng F
PROVIDER: S-EPMC6696179 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Zeng Fanxun F Quan Lina L Yang Guantian G Qi Tiantian T Zhang Letian L Li Shiliang S Li Honglin H Zhu Lili L Xu Xiaoyong X
Molecules (Basel, Switzerland) 20190731 15
Human dihydroorotate dehydrogenase (<i>h</i>DHODH), one of the attractive targets for the development of immunosuppressive drugs, is also a potential target of anticancer drugs and anti-leukemic drugs. The development of promising <i>h</i>DHODH inhibitors is in high demand. Based on the unique binding mode of our previous reported 4-thiazolidinone derivatives, via molecular docking method, three new series 4-thiazolidinone derivatives were designed and synthesized as <i>h</i>DHODH inhibitors. Th ...[more]