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Limitations of Fat-Free Mass for the Assessment of Muscle Mass in Obesity.


ABSTRACT:

Background

A high amount of adipose tissue limits the accuracy of methods for body composition analysis in obesity.

Objectives

The aim was to quantify and explain differences in fat-free mass (FFM) (as an index of skeletal muscle mass, SMM) measured with bioelectrical impedance analysis (BIA), dual energy X-ray absorptiometry (DXA), air displacement plethysmography (ADP), and deuterium dilution in comparison to multicompartment models, and to improve the results of BIA for obese subjects.

Methods

In 175 healthy subjects (87 men and 88 women, BMI 20-43.3 kg/m2, 18-65 years), FFM measured by these methods was compared with results from a 3- (3C) and a 4-compartment (4C) model. FFM4C was compared with SMM measured by magnetic resonance imaging.

Results

BIA and DXA overestimated and ADP underestimated FFM in comparison to 3C and 4C models with increasing BMI (all p < 0.001). -Differences were largest for DXA. In obesity, BIA results were improved: valuecorrected = -valueuncorrected - a(BMI - 30 kg/m2), a = 0.256 for FFM and a = 0.298 for SMM. SMM accounts for 45% of FFM in women and 49% in men.

Conclusions

In obesity, the use of FFM is limited by a systematic error of reference methods. In addition, SMM accounts for about 50% of FFM only. Corrected measurement of SMM by BIA can overcome these drawbacks.

SUBMITTER: Jensen B 

PROVIDER: S-EPMC6696776 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Limitations of Fat-Free Mass for the Assessment of Muscle Mass in Obesity.

Jensen Björn B   Braun Wiebke W   Geisler Corinna C   Both Markus M   Klückmann Kristin K   Müller Manfred J MJ   Bosy-Westphal Anja A  

Obesity facts 20190527 3


<h4>Background</h4>A high amount of adipose tissue limits the accuracy of methods for body composition analysis in obesity.<h4>Objectives</h4>The aim was to quantify and explain differences in fat-free mass (FFM) (as an index of skeletal muscle mass, SMM) measured with bioelectrical impedance analysis (BIA), dual energy X-ray absorptiometry (DXA), air displacement plethysmography (ADP), and deuterium dilution in comparison to multicompartment models, and to improve the results of BIA for obese s  ...[more]

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