Ontology highlight
ABSTRACT:
SUBMITTER: Huang Y
PROVIDER: S-EPMC6697584 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Huang Yujie Y Fang Jiansong J Lu Weiqiang W Wang Zihao Z Wang Qi Q Hou Yuan Y Jiang Xingwu X Reizes Ofer O Lathia Justin J Nussinov Ruth R Eng Charis C Cheng Feixiong F
Cell chemical biology 20190606 8
Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous disease that lacks clinically actionable genetic alterations that limit targeted therapies. Here we explore a systems pharmacology approach that integrates drug-target networks and large-scale genomic profiles of TNBC and identify wogonoside, one of the major active flavonoids, as a potent angiogenesis inhibitor. We validate that wogonoside attenuates cell migration, tube formation, and rat aorta microvessel outgrowth, and r ...[more]