Ontology highlight
ABSTRACT:
SUBMITTER: Di Mauro C
PROVIDER: S-EPMC5520095 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Di Mauro Concetta C Rosa Roberta R D'Amato Valentina V Ciciola Paola P Servetto Alberto A Marciano Roberta R Orsini Roberta Clara RC Formisano Luigi L De Falco Sandro S Cicatiello Valeria V Di Bonito Maurizio M Cantile Monica M Collina Francesca F Chambery Angela A Veneziani Bianca Maria BM De Placido Sabino S Bianco Roberto R
British journal of cancer 20170425 11
<h4>Background</h4>Several evidences suggest a marked angiogenic dependency in triple-negative breast cancer (TNBC) tumorigenesis and a potential sensitivity to anti-angiogenic agents. Herein, the putative role of Hedgehog (Hh) pathway in regulating TNBC-dependent angiogenesis was investigated.<h4>Methods</h4>Expression and regulation of the Hh pathway transcription factor glioma-associated oncogene homolog1 protein (GLI1) were studied on the endothelial compartment and on TNBC-initiated angioge ...[more]