Ontology highlight
ABSTRACT:
SUBMITTER: Mohammad AH
PROVIDER: S-EPMC6697641 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Mohammad Amro H AH Assadian Sarah S Couture Frédéric F Lefebvre Karen J KJ El-Assaad Wissal W Barrès Veronique V Ouellet Veronique V Boulay Pierre-Luc PL Yang Jieyi J Latour Mathieu M Furic Luc L Muller William W Sonenberg Nahum N Mes-Masson Anne-Marie AM Saad Fred F Day Robert R Teodoro Jose G JG
Oncotarget 20190813 48
Phosphatase and tensin homolog (PTEN) tumor suppressor protein loss is common in prostate cancer (PCa). PTEN loss increases PI3K/Akt signaling, which promotes cell growth and survival. To find secreted biomarkers of PTEN loss, a proteomic screen was used to compare secretomes of cells with and without PTEN expression. We showed that PTEN downregulates Prorenin Receptor (PRR) expression and secretion of soluble Prorenin Receptor (sPRR) in PCa cells and in mouse. PRR is an accessory protein requir ...[more]