Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez M
PROVIDER: S-EPMC4683109 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Rodriguez M M Siwko S S Zeng L L Li J J Yi Z Z Liu M M
Oncogene 20150601 9
Among frequent events in prostate cancer are loss of the tumor-suppressor phosphatase and tensin homologue (PTEN) and overexpression of prostate-specific G-protein-coupled receptor (PSGR), but the potential tumorigenic synergy between these lesions is unknown. Here, we report a new mouse model (PSGR-Pten(Δ/Δ)) combining prostate-specific loss of Pten with probasin promoter-driven PSGR overexpression. By 12 months PSGR-Pten(Δ/Δ) mice developed invasive prostate tumors featuring Akt activation and ...[more]