Ontology highlight
ABSTRACT:
SUBMITTER: Boopathy AV
PROVIDER: S-EPMC6697788 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Boopathy Archana V AV Mandal Anasuya A Kulp Daniel W DW Menis Sergey S Bennett Nitasha R NR Watkins Hannah C HC Wang Wade W Martin Jacob T JT Thai Nikki T NT He Yanpu Y Schief William R WR Hammond Paula T PT Irvine Darrell J DJ
Proceedings of the National Academy of Sciences of the United States of America 20190729 33
Sustained exposure of lymphoid tissues to vaccine antigens promotes humoral immunity, but traditional bolus immunizations lead to rapid antigen clearance. We describe a technology to tailor vaccine kinetics in a needle-free platform translatable to human immunization. Solid pyramidal microneedle (MN) arrays were fabricated with silk fibroin protein tips encapsulating a stabilized HIV envelope trimer immunogen and adjuvant, supported on a dissolving polymer base. Upon brief skin application, vacc ...[more]