Ontology highlight
ABSTRACT:
SUBMITTER: Mistilis MJ
PROVIDER: S-EPMC5750137 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Mistilis Matthew J MJ Bommarius Andreas S AS Prausnitz Mark R MR
Journal of pharmaceutical sciences 20141201 2
The goal of this study is to develop thermostable microneedle patch formulations for influenza vaccine that can be partially or completely removed from the cold chain. During vaccine drying associated with microneedle patch manufacturing, ammonium acetate and 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) buffer salts stabilized influenza vaccine, surfactants had little effect during drying, drying temperature had weak effects on vaccine stability, and drying on polydimethylsiloxane ...[more]