Impact of antiretroviral treatment on height evolution of HIV infected children.

ABSTRACT: BACKGROUND:Antiretroviral treatment (ART) has been shown to have a beneficial effect on the weight evolution but its effect on height remains unclear. We described patterns of height evolution and identified predictors of catch-up growth in HIV-infected children on ART. METHODS:To describe the height evolution from birth to adulthood, we developed a nonlinear mixed effect model using data from perinatally HIV-infected children who initiated ART from 1999 to 2013 in a prospective cohort study in Thailand. The main covariates of interest were: sex, ART regimen (dual nucleoside reverse-transcriptase inhibitor, non-nucleoside reverse transcriptase inhibitor (NNRTI)-, or protease inhibitor (PI)-based), baseline CD4 percentage, HIV-RNA load and CDC HIV Classification stage and occurrence of AIDS-defining events. RESULTS:A total 477 children (43% boys) contributed 18,596 height measurements over a median duration of 6.3?years on ART (interquartile range, 3.0 to 8.3). At ART initiation, median age was 6.2?years (1.8 to 9.6), 16% of children were underweight (weight-for-age z-score?

SUBMITTER: Traisathit P 

PROVIDER: S-EPMC6697969 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature