Ontology highlight
ABSTRACT:
SUBMITTER: Lee J
PROVIDER: S-EPMC6698916 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Lee Jiyoung J Yesilkanal Ali E AE Wynne Joseph P JP Frankenberger Casey C Liu Juan J Yan Jielin J Elbaz Mohamad M Rabe Daniel C DC Rustandy Felicia D FD Tiwari Payal P Grossman Elizabeth A EA Hart Peter C PC Kang Christie C Sanderson Sydney M SM Andrade Jorge J Nomura Daniel K DK Bonini Marcelo G MG Locasale Jason W JW Rosner Marsha Rich MR
Nature 20190306 7751
Mitochondrial metabolism is an attractive target for cancer therapy<sup>1,2</sup>. Reprogramming metabolic pathways could improve the ability of metabolic inhibitors to suppress cancers with limited treatment options, such as triple-negative breast cancer (TNBC)<sup>1,3</sup>. Here we show that BTB and CNC homology1 (BACH1)<sup>4</sup>, a haem-binding transcription factor that is increased in expression in tumours from patients with TNBC, targets mitochondrial metabolism. BACH1 decreases glucose ...[more]