Ontology highlight
ABSTRACT:
SUBMITTER: Braxton CN
PROVIDER: S-EPMC6699165 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Braxton Courtney N CN Quartner Evan E Pawloski Westley W Fushman David D Cropp T Ashton TA
Biochemistry 20190201 7
Ubiquitin-mediated signaling pathways regulate essentially every aspect of cell biology in eukaryotes. Ubiquitin receptors typically contain ubiquitin-binding domains (UBDs) that have the ability to recognize monomeric ubiquitin (Ub) and polymeric Ub (polyUb) chains. However, how signaling specificity is achieved remains poorly understood, and many of the UBDs that selectively recognize polyUb chains of particular linkages still need to be identified and characterized. Here we report the incorpo ...[more]