Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC6699389 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Wang Ying Y Ru Jidong J Jin Tao T Sun Ming M Jia Lizhu L Sun Guijiang G
BioMed research international 20190730
MicroRNAs (miRNAs) and single nucleotide polymorphisms (SNPs) play important roles in disease risk and development, especially cancer. Importantly, when SNPs are located in pre-miRNAs, they affect their splicing mechanism and change the function of miRNAs. To improve disease risk assessment, we propose an approach and developed a software tool, IsomiR_Find, to identify disease/phenotype-related SNPs and isomiRs in individuals. Our approach is based on the individual's samples, with SNP informati ...[more]