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Single nucleotide polymorphisms in microRNAs action as biomarkers for breast cancer.

ABSTRACT: MicroRNAs (miRNAs) have been recently described as small noncoding RNAs that are involved in numerous crucial physiological processes, such as cell cycles, differentiation, development, and metabolism. Thus, dysregulation of these molecules could lead to several severe disorders, including breast cancer (BC). Ongoing investigations in malignant growth diagnostics have distinguished miRNAs as promising disease biomarkers. As with any other mRNAs, single nucleotide polymorphisms (SNPs) in DNA sequence encoding for miRNA (miR-SNPs) indeed lead to potential changes in the function of miRNA. In this study, miR-SNPs located in different miRNA sequence regions, which have been associated with BC in different ways, and the potential mechanisms of how these miR-SNPs develop the risk of the disease were discussed.

SUBMITTER: Nguyen TTN

PROVIDER: S-EPMC7585164 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Single nucleotide polymorphisms in microRNAs action as biomarkers for breast cancer.

Nguyen Thanh Thi Ngoc TTN Tran Minh Thi Hong MTH Nguyen Vy Thi Lan VTL Nguyen Uyen Doan Phuong UDP Nguyen Giang Dien Thanh GDT Huynh Luan Huu LH Nguyen Hue Thi HT

Turkish journal of biology = Turk biyoloji dergisi 20201013 5

MicroRNAs (miRNAs) have been recently described as small noncoding RNAs that are involved in numerous crucial physiological processes, such as cell cycles, differentiation, development, and metabolism. Thus, dysregulation of these molecules could lead to several severe disorders, including breast cancer (BC). Ongoing investigations in malignant growth diagnostics have distinguished miRNAs as promising disease biomarkers. As with any other mRNAs, single nucleotide polymorphisms (SNPs) in DNA sequ ...[more]

PMID: 33110366

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