Ontology highlight
ABSTRACT:
SUBMITTER: Quispe PA
PROVIDER: S-EPMC6699424 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Quispe Patricia A PA Lavecchia Martin J MJ León Ignacio E IE
Heliyon 20190810 8
Survivin protein is a metalloprotein member of the inhibitors of apoptosis proteins family, involved in the regulation of programmed cell death. Due to the recent development of antitumor therapies having survivin as molecular target, several strategies to interfere with the expression or function of survivin have emerged. This work describes the discovery of a new potential inhibitor of survivin function using a computer-aided drug design approach. Structure-based virtual screening and molecula ...[more]