Ontology highlight
ABSTRACT:
SUBMITTER: Youn K
PROVIDER: S-EPMC7601397 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Youn Kumju K Yoon Jeong-Hyun JH Lee Nayoung N Lim Gyutae G Lee Jinhyuk J Sang Shengmin S Ho Chi-Tang CT Jun Mira M
Nutrients 20201002 10
BACE1 is the rate-limiting enzyme involved in the production and deposition of β-amyloid (Aβ). Since neurotoxic Aβ plays a critical role in Alzheimer's disease (AD) pathogenesis, BACE1 has emerged as a key target for preventing AD. In the present study, the potential of sulforaphane, an isothiocyanate found in cruciferous vegetables, as a BACE1 inhibitor has been investigated. Sulforaphane exhibited six times more potent activity against BACE1 compared to well-known positive controls including r ...[more]