Development of fluorinated naphthofluoresceins for Cerenkov imaging.
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ABSTRACT:
SUBMITTER: Arroyo AD
PROVIDER: S-EPMC6699748 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Development of fluorinated naphthofluoresceins for Cerenkov imaging.
Arroyo Alejandro D AD Guzmán Andrea E AE Kachur Alexander V AV Saylor Sarah J SJ Popov Anatoliy V AV Delikatny E James EJ
Journal of fluorine chemistry 20190524
In this paper, we report the synthesis and characterization of fluorinated derivatives of naphthofluorescein (NF), a fluorescent pH-sensitive probe that can be used for functional Cerenkov imaging. The compounds were prepared using electrophilic fluorination with dilute fluorine gas under acidic conditions. The fluorination of the NF molecule occurred in the <i>ortho</i> positions to the hydroxyl moiety, producing mono-, di-, and tri-substituted derivatives. The properties of the fluorinated nap ...[more]
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