Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients.
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ABSTRACT:
SUBMITTER: Serebriiskii IG
PROVIDER: S-EPMC6700103 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients.
Serebriiskii Ilya G IG Connelly Caitlin C Frampton Garrett G Newberg Justin J Cooke Matthew M Miller Vince V Ali Siraj S Ross Jeffrey S JS Handorf Elizabeth E Arora Sanjeevani S Lieu Christopher C Golemis Erica A EA Meyer Joshua E JE
Nature communications 20190819 1
Colorectal cancer (CRC) is increasingly appreciated as a heterogeneous disease, with factors such as microsatellite instability (MSI), cancer subsite within the colon versus rectum, and age of diagnosis associated with specific disease course and therapeutic response. Activating oncogenic mutations in KRAS and NRAS are common in CRC, driving tumor progression and influencing efficacy of both cytotoxic and targeted therapies. The RAS mutational spectrum differs substantially between tumors arisin ...[more]
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