Ontology highlight
ABSTRACT:
SUBMITTER: Kleiman LB
PROVIDER: S-EPMC3861465 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Kleiman Laura B LB Krebs Angela M AM Kim Stephen Y SY Hong Theodore S TS Haigis Kevin M KM
PloS one 20131212 12
Approximately 40% of rectal cancers harbor activating K-RAS mutations, and these mutations are associated with poor clinical response to chemoradiotherapy. We aimed to identify small molecule inhibitors (SMIs) that synergize with ionizing radiation (IR) ("radiosensitizers") that could be incorporated into current treatment strategies for locally advanced rectal cancers (LARCs) expressing mutant K-RAS. We first optimized a high-throughput assay for measuring individual and combined effects of SMI ...[more]