Isolation and characterization of a novel oligomeric proanthocyanidin with significant anti-cancer activities from grape stems (Vitis vinifera).
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ABSTRACT:
SUBMITTER: Sei-Ichi K
PROVIDER: S-EPMC6700121 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
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Isolation and characterization of a novel oligomeric proanthocyanidin with significant anti-cancer activities from grape stems (Vitis vinifera).
Sei-Ichi Kawahara K Toda Kazuya K Matsumoto Kiriko K Ishihara Chisato C Nonobe Shuhei S Matsunaga Chisato C Gomi Yoshika K YK Senga Shogo S Kawaguchi Koichiro K Yamamoto Ayaka A Suwannachot Jutalak J Noda Reiko R Kobayashi Shuhei S Hamauzu Yasunori Y Makabe Hidefumi H Fujii Hiroshi H
Scientific reports 20190819 1
Novel proanthocyanidin fractions from grape stem extracts were purified using Amberlite XAD-1180N, Sephadex-LH-20, Toyopearl HW40F and reverse phase high-performance liquid chromatography. Two key compounds were estimated as epigallocatechin-(epicatechin)<sub>7</sub> gallate using electron-spray ionization time-of-flight mass spectrometry. Epigallocatechin-(epicatechin)<sub>7</sub> gallate (compound 1) showed significant anti-cancer activity in PC-3 prostate cancer cells. In particular, compound ...[more]
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