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An Efficient Approach to Aromatic Aminomethylation Using Dichloromethane as Methylene Source.

ABSTRACT: Ultrasound-promoted N-aminomethylation of indoles can be achieved in basic medium using sodium hydride and dichloromethane (DCM) as C1 donor source. This innovative amino methylation protocol results in good to excellent yields of multifunctional indole derivatives. The procedure is also applicable to other aza-heterocyclic compounds and, interestingly, affords direct access to aminomethyl-substituted aryl alcohols.

SUBMITTER: Ostacolo C

PROVIDER: S-EPMC6700257 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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An Efficient Approach to Aromatic Aminomethylation Using Dichloromethane as Methylene Source.

Ostacolo Carmine C Di Sarno Veronica V Musella Simona S Ciaglia Tania T Vestuto Vincenzo V Pepe Giacomo G Merciai Fabrizio F Campiglia Pietro P Gomez Monterrey Isabel M IM Bertamino Alessia A

Frontiers in chemistry 20190813

Ultrasound-promoted N-aminomethylation of indoles can be achieved in basic medium using sodium hydride and dichloromethane (DCM) as C1 donor source. This innovative amino methylation protocol results in good to excellent yields of multifunctional indole derivatives. The procedure is also applicable to other aza-heterocyclic compounds and, interestingly, affords direct access to aminomethyl-substituted aryl alcohols. ...[more]

PMID: 31457005

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