Dataset Information

Associations of Chronic Kidney Disease Markers with Cognitive Function: A 12-Year Follow-Up Study.

ABSTRACT:

Background

The role of chronic kidney disease (CKD) as a risk factor for cognitive impairment independent of their shared antecedents remains controversial.

Objective

To determine whether kidney damage (indicated by albuminuria) or kidney dysfunction (estimated glomerular filtration rate [eGFR]?<60?ml/min/1.73 m2) predict future (12-year) cognitive function independently of their shared risk factors.

Methods

We studied 4,128 individuals from the 1999/00 population-based Australian Diabetes, Obesity, and Lifestyle (AusDiab) Study who returned in 2011/12 for follow-up cognitive function testing. Albuminuria was defined by urinary albumin:creatinine?3.5 (women) or?2.5?mg/mmol (men). Kidney dysfunction was indicated by eGFR?<60?ml/min/1.73 m2. Cognitive function domains assessed included memory (California Verbal Learning Test [CVLT]) and processing speed (Symbol Digit Modalities Test [SDMT]).

Results

Baseline albuminuria and kidney dysfunction were identified in 142 (3.4%) and 39 (0.9%) individuals, respectively, with minimal overlap (n?=?7). Those with albuminuria demonstrated concurrently reduced 12-year SDMT (p?=?0.084) and CVLT scores (p?=?0.005) following adjustment for age, sex, and education. However, only CVLT performance remained worse (p?=?0.027) following additional adjustment for myocardial infarction, stroke, and related risk factors (hypertension, diabetes, dyslipidemia, smoking, BMI, physical activity, and alcohol intake). Indeed, these collective covariates were responsible for 47% of the effect of albuminuria on SDMT, but only 21% of its effect on CVLT. Kidney dysfunction was not associated with either SDMT or CVLT performance (p?>?0.10).

Conclusions

Albuminuria predicted worse memory function at 12 years follow-up, whereas its effect on processing speed was driven largely by differences in cardiovascular risk. Kidney dysfunction based on eGFR predicted neither cognitive domain.

SUBMITTER: Sacre JW

PROVIDER: S-EPMC6700620 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Associations of Chronic Kidney Disease Markers with Cognitive Function: A 12-Year Follow-Up Study.

Sacre Julian W JW Magliano Dianna J DJ Zimmet Paul Z PZ Polkinghorne Kevan R KR Chadban Steven J SJ Anstey Kaarin J KJ Shaw Jonathan E JE

Journal of Alzheimer's disease : JAD 20190101 s1

<h4>Background</h4>The role of chronic kidney disease (CKD) as a risk factor for cognitive impairment independent of their shared antecedents remains controversial.<h4>Objective</h4>To determine whether kidney damage (indicated by albuminuria) or kidney dysfunction (estimated glomerular filtration rate [eGFR] <60 ml/min/1.73 m2) predict future (12-year) cognitive function independently of their shared risk factors.<h4>Methods</h4>We studied 4,128 individuals from the 1999/00 population-based Aus ...[more]

PMID: 30372677

Similar Datasets

Project description:There have been few prospective controlled studies of kidney donors. Understanding the pathophysiologic effects of kidney donation is important for judging donor safety and improving our understanding of the consequences of reduced kidney function in chronic kidney disease.Prospective, controlled, observational cohort study.3-year follow-up of kidney donors and paired controls suitable for donation at their donor's center.Kidney donation.Medical history, vital signs, glomerular filtration rate, and other measurements at 6, 12, 24, and 36 months after donation.At 36 months, 182 of 203 (89.7%) original donors and 173 of 201 (86.1%) original controls continue to participate in follow-up visits. The linear slope of the glomerular filtration rate measured by plasma iohexol clearance declined 0.36±7.55mL/min per year in 194 controls, but increased 1.47±5.02mL/min per year in 198 donors (P=0.005) between 6 and 36 months. Blood pressure was not different between donors and controls at any visit, and at 36 months, all 24-hour ambulatory blood pressure parameters were similar in 126 controls and 135 donors (mean systolic blood pressure, 120.0±11.2 [SD] vs 120.7±9.7mmHg [P=0.6]; mean diastolic blood pressure, 73.4±7.0 vs 74.5±6.5mmHg [P=0.2]). Mean arterial pressure nocturnal dipping was manifest in 11.2% ± 6.6% of controls and 11.3% ± 6.1% of donors (P=0.9). Urinary protein-creatinine and albumin-creatinine ratios were not increased in donors compared with controls. From 6 to 36 months postdonation, serum parathyroid hormone, uric acid, homocysteine, and potassium levels were higher, whereas hemoglobin levels were lower, in donors compared with controls.Possible bias resulting from an inability to select controls screened to be as healthy as donors, short follow-up duration, and dropouts.Kidney donors manifest several of the findings of mild chronic kidney disease. However, at 36 months after donation, kidney function continues to improve in donors, whereas controls have expected age-related declines in function.

Dataset Information

Associations of Chronic Kidney Disease Markers with Cognitive Function: A 12-Year Follow-Up Study.

Background

Objective

Methods

Results

Conclusions

Publications

Associations of Chronic Kidney Disease Markers with Cognitive Function: A 12-Year Follow-Up Study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets