Dataset Information

Variability in the burden of disease estimates with or without age weighting and discounting: a methodological study.

ABSTRACT:

Objectives

This study examines the impact of the type of method used on the estimation of the burden of diseases.

Design

Comparison of methods of estimating disease burden.

Setting

Four metrics of burden of disease estimation, namely, years of potential life lost (YPLL), non-age weighted years of life lost (YLL) without discounting and YLL with uniform or non-uniform age weighting and discounting were used to calculate the burden of selected diseases in three countries: Australia, USA and South Africa.

Participants

Mortality data for all individuals from birth were obtained from the WHO database.

Outcomes

The burden of 10 common diseases with four metrices, and the relative contribution of each disease to the overall national burden when each metric is used.

Results

There were variations in the burden of disease estimates with the four methods. The standardised YPLL estimates were higher than other methods of calculation for diseases common among young adults and lower for diseases common among the elderly. In the three countries, discounting decreased the contributions of diseases common among younger adults to the total burden of disease, while the contributions of diseases of the elderly increased. After discounting with age weighting, there were no distinct patterns for diseases of the elderly and young adults in the three countries.

Conclusions

Given the variability in the estimates of the burden of disease with different approaches, there should be transparency regarding the type of metric used and a generally acceptable method that incorporates all the relevant social values should be developed.

SUBMITTER: Egunsola O

PROVIDER: S-EPMC6701586 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Variability in the burden of disease estimates with or without age weighting and discounting: a methodological study.

Egunsola Oluwaseun O Raubenheimer Jacques J Buckley Nicholas N

BMJ open 20190818 8

<h4>Objectives</h4>This study examines the impact of the type of method used on the estimation of the burden of diseases.<h4>Design</h4>Comparison of methods of estimating disease burden.<h4>Setting</h4>Four metrics of burden of disease estimation, namely, years of potential life lost (YPLL), non-age weighted years of life lost (YLL) without discounting and YLL with uniform or non-uniform age weighting and discounting were used to calculate the burden of selected diseases in three countries: Aus ...[more]

PMID: 31427320

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Project description:Background:Cervical cancer represents an important preventable cause of morbidity and mortality in developing countries such as Brazil. Investigating temporal evolution of a disease burden in the different realities of the country is essential for improving public policies. Objective:To describe the national and subnational burden of cervical cancer, based on the estimates of the 2017 Global Burden of Disease study. Methods:Descriptive study of premature mortality (years of life lost [YLL]) and burden of disease (disability-adjusted life years [DALYs]) associated with cervical cancer among Brazilian women aged 25-64 years, between 2000 and 2017. Findings:During the study period, age-standardized incidence decreased from 23.53 (22.79-24.26) to 18.39 (17.63-19.17) per 100,000 women, while mortality rates decreased from 11.3 (11.05-11.56) to 7.74 (7.49-8.02) per 100,000 women. These rates were about two to three times greater than equivalent rates in a developed country, such as England: 11.98 (11.45-12.55) to 10.37 (9.85-10.9), and 3.75 (3.68-3.84) to 2.82 (2.75-2.9) per 100,000 women, respectively. Poorer regions of Brazil had greater rates of the disease; for instance, Amapá State in the Northern Region had rates twice as high as the national rates during the same period. Cervical cancer was the leading cause of premature cancer-related mortality (YLL = 100.69, 91.48-110.61 per 100,000 women) among young women (25-29 years) in Brazil and eight federation units of all country regions except the Southeast in 2017. There was a decrease in the burden of cervical cancer in Brazil from 339.59 (330.82-348.83) DALYs per 100,000 women in 2000 to 238.99 (230.45-247.99) DALYs per 100,000 women in 2017. Conclusion:Although there has been a reduction in the burden of cervical cancer in Brazil, the rates remain high, mainly among young women. The persistence of inequalities between regions of Brazil suggests the importance of socioeconomic determinants in the burden for this cancer.

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Dataset Information

Variability in the burden of disease estimates with or without age weighting and discounting: a methodological study.

Objectives

Design

Setting

Participants

Outcomes

Results

Conclusions

Publications

Variability in the burden of disease estimates with or without age weighting and discounting: a methodological study.

Similar Datasets

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