Ontology highlight
ABSTRACT:
SUBMITTER: Yang BH
PROVIDER: S-EPMC6701704 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Cell reports 20190601 12
CD4<sup>+</sup> Foxp3<sup>+</sup> T regulatory (Treg) cells are key players in preventing lethal autoimmunity. Tregs undertake differentiation processes and acquire diverse functional properties. However, how Treg's differentiation and functional specification are regulated remains incompletely understood. Here, we report that gradient expression of TCF1 and LEF1 distinguishes Tregs into three distinct subpopulations, particularly highlighting a subset of activated Treg (aTreg) cells. Treg-speci ...[more]