Ontology highlight
ABSTRACT:
SUBMITTER: Abdul Qayum A
PROVIDER: S-EPMC6702076 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Abdul Qayum Amina A Koh Byunghee B Martin Rebecca K RK Kenworthy Blake T BT Kharwadkar Rakshin R Fu Yongyao Y Wu Wenting W Conrad Daniel H DH Kaplan Mark H MH
Journal of immunology (Baltimore, Md. : 1950) 20190726 5
IL-9 is an important mediator of allergic disease that is critical for mast cell-driven diseases. IL-9 is produced by many cell types, including T cells, basophils, and mast cells. Yet, how IL-9 is regulated in mast cells or basophils is not well characterized. In this report, we tested the effects of deficiency of a mouse <i>Il9</i> gene regulatory element (<i>Il9</i> CNS-25) in these cells in vivo and in vitro. In mast cells stimulated with IL-3 and IL-33, the <i>Il9</i> CNS-25 enhancer is a p ...[more]