Ontology highlight
ABSTRACT:
SUBMITTER: Kazantseva M
PROVIDER: S-EPMC6702175 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Kazantseva Marina M Mehta Sunali S Eiholzer Ramona A RA Gimenez Gregory G Bowie Sara S Campbell Hamish H Reily-Bell Ashley L AL Roth Imogen I Ray Sankalita S Drummond Catherine J CJ Reid Glen G Joruiz Sebastien M SM Wiles Anna A Morrin Helen R HR Reader Karen L KL Hung Noelyn A NA Baird Margaret A MA Slatter Tania L TL Braithwaite Antony W AW
Cell death & disease 20190820 9
Prostate cancer is the second most common cancer in men, for which there are no reliable biomarkers or targeted therapies. Here we demonstrate that elevated levels of Δ133TP53β isoform characterize prostate cancers with immune cell infiltration, particularly T cells and CD163+ macrophages. These cancers are associated with shorter progression-free survival, Gleason scores ≥ 7, and an immunosuppressive environment defined by a higher proportion of PD-1, PD-L1 and colony-stimulating factor 1 recep ...[more]