Hippocampal volume change following ECT is mediated by rs699947 in the promotor region of VEGF.
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ABSTRACT:
SUBMITTER: Van Den Bossche MJA
PROVIDER: S-EPMC6702208 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
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Hippocampal volume change following ECT is mediated by rs699947 in the promotor region of VEGF.
Van Den Bossche Maarten J A MJA Emsell Louise L Dols Annemiek A Vansteelandt Kristof K De Winter François-Laurent FL Van den Stock Jan J Sienaert Pascal P Stek Max L ML Bouckaert Filip F Vandenbulcke Mathieu M
Translational psychiatry 20190820 1
Several studies have shown that electroconvulsive therapy (ECT) results in increased hippocampal volume. It is likely that a multitude of mechanisms including neurogenesis, gliogenesis, synaptogenesis, angiogenesis, and vasculogenesis contribute to this volume increase. Neurotrophins, like vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF) seem to play a crucial mediating role in several of these mechanisms. We hypothesized that two regulatory SNPs in the VEGF ...[more]
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Project description:BackgroundElectroconvulsive therapy (ECT) is one of the most effective treatments for depression and schizophrenia, particularly in urgent or treatment-resistant cases. After ECT, regional gray matter volume (GMV) increases have been repeatedly reported both in depression and schizophrenia. However, the interpretation of these findings remains entangled because GMV changes do not necessarily correlate with treatment effects and may be influenced by the intervention itself. We hypothesized that the comparison of longitudinal magnetic resonance imaging data between the two diagnostic groups will provide clues to distinguish diagnosis-specific and transdiagnostic changes.MethodTwenty-nine Japanese participants, including 18 inpatients with major depressive disorder and 11 with schizophrenia, underwent longitudinal voxel-based morphometry before and after ECT. We investigated GMV changes common to both diagnostic groups and those specific to each group. Moreover, we also evaluated potential associations between GMV changes and clinical improvement for each group.ResultsIn both diagnostic groups, GMV increased in widespread areas after ECT, sharing common regions including: anterior temporal cortex; medial frontal and anterior cingulate cortex; insula; and caudate nucleus. In addition, we found a schizophrenia-specific GMV increase in a region including the left pregenual anterior cingulate cortex, with volume increase significantly correlating with clinical improvement.ConclusionsTransdiagnostic volume changes may represent the effects of the intervention itself and pathophysiological changes common to both groups. Conversely, diagnosis-specific volume changes are associated with treatment effects and may represent pathophysiology-specific impacts of ECT.
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