Ontology highlight
ABSTRACT:
SUBMITTER: Lentini NA
PROVIDER: S-EPMC6703555 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20180926 19
Small organophosphorus compounds stimulate Vγ9 Vδ2 T cells if they serve as ligands of butyrophilin 3A1. Because the most potent natural ligand is ( E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP), which is the last intermediate in bacterial biosynthesis of isoprenoids that is not found in mammalian metabolism, activation of these T cells represents an important component of the immune response to bacterial infections. To identify butyrophilin ligands that may have greater plasma stability, ...[more]