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Transcriptome analysis of blood Vγ9 Vδ2 gdT cells upon TCR and Notch signalling

ABSTRACT: We utilized RNA-seq to identify differential gene expression in Vγ9 Vδ2 gdT cells isolated from human PBMCs upon TCR stimulation. We find that ~30% genes are commonly up- and down-regulated between different phosphoantigen treatments (p<0.05). Inhibition of Notch signaling alongside TCR activation results in downregulation of many effector genes in Vγ9 Vδ2 T cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE168642 | GEO | 2021/08/25

REPOSITORIES: GEO

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