Ontology highlight
ABSTRACT:
SUBMITTER: Cao L
PROVIDER: S-EPMC6704105 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Cao Lixue L Wu Geyan G Zhu Jinrong J Tan Zhanyao Z Shi Dongni D Wu Xingui X Tang Miaoling M Li Ziwen Z Hu Yameng Y Zhang Shuxia S Yu Ruyuan R Mo Shuang S Wu Jueheng J Song Erwei E Li Mengfeng M Song Libing L Li Jun J
Nature communications 20190821 1
The mechanisms underlying how cells subjected to genotoxic stress reestablish reduction-oxidation (redox) homeostasis to scavenge genotoxic stress-induced reactive oxygen species (ROS), which maintains the physiological function of cellular processes and cell survival, remain unclear. Herein, we report that, via a TCF-independent mechanism, genotoxic stress induces the enrichment of β-catenin in chromatin, where it forms a complex with ATM phosphorylated-JDP2 and PRMT5. This elicits histone H3R2 ...[more]