Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy.
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ABSTRACT:
SUBMITTER: Hathout Y
PROVIDER: S-EPMC6704115 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy.
Hathout Yetrib Y Liang Chen C Ogundele Michael M Xu Ganggang G Tawalbeh Shefa M SM Dang Utkarsh J UJ Hoffman Eric P EP Gordish-Dressman Heather H Conklin Laurie S LS van den Anker John N JN Clemens Paula R PR Mah Jean K JK Henricson Erik E McDonald Craig C
Scientific reports 20190821 1
Extensive biomarker discoveries for DMD have occurred in the past 7 years, and a vast array of these biomarkers were confirmed in independent cohorts and across different laboratories. In these previous studies, glucocorticoids and age were two major confounding variables. In this new study, using SomaScan technology and focusing on a subset of young DMD patients who were not yet treated with glucocorticoids, we identified 108 elevated and 70 decreased proteins in DMD relative to age matched hea ...[more]
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