Ontology highlight
ABSTRACT:
SUBMITTER: Sonthonnax F
PROVIDER: S-EPMC6704159 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Sonthonnax Florian F Besson Benoit B Bonnaud Emilie E Jouvion Grégory G Merino David D Larrous Florence F Bourhy Hervé H
Scientific reports 20190821 1
Phosphoprotein (P) and matrix protein (M) cooperate to undermine the immune response to rabies virus (RABV) infections. While P is involved in the modulation of the Jak-Stat pathway through the cytoplasmic retention of interferon (IFN)-activated STAT1 (pSTAT1), M interacts with the RelAp43-p105-ABIN2-TPL2 complex, to efficiently inhibit the nuclear factor-κB (NF-κB) pathway. Using transfections, protein-complementation assays, reverse genetics and DNA ChIP, we identified a role of M protein in t ...[more]