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A combined view of B-cell epitope features in antigens.


ABSTRACT: B-cell epitope mapping is a promising approach to identify therapeutics and vaccine candidates in antigenic proteins. We used MATLAB programming to view in combination different features such as beta turn region, surface accessibility, antigenicity and hydrophilicity in an antigen sequence to help predict a discontinuous, conformational B-cell epitope. We analyzed, grouped, compared, matched and superposed these features for a combined visualization using MATLAB programming for identifying and illustrating a potential B-cell epitope region in an antigen protein. This protocol finds application in the design and development of an effective B cell epitope candidate.

SUBMITTER: Zobayer N 

PROVIDER: S-EPMC6704334 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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A combined view of B-cell epitope features in antigens.

Zobayer Nayem N   Hossain Abm Aowlad AA   Rahman Md Asadur MA  

Bioinformation 20190815 7


B-cell epitope mapping is a promising approach to identify therapeutics and vaccine candidates in antigenic proteins. We used MATLAB programming to view in combination different features such as beta turn region, surface accessibility, antigenicity and hydrophilicity in an antigen sequence to help predict a discontinuous, conformational B-cell epitope. We analyzed, grouped, compared, matched and superposed these features for a combined visualization using MATLAB programming for identifying and i  ...[more]

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