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ABSTRACT: Background
Oedema, characterized by accumulation of extracellular water (ECW), is one of the major clinical manifestations in children suffering from nephrotic syndrome (NS). The lack of a simple, inexpensive and harmless method for assessing ECW may be solved by the use of the bioelectrical impedance analysis (BIA) technique. The aims of this study were to examine whether phase angle (PA), bioelectrical impedance vector analysis (BIVA) and the impedance ratio (IR) reflect change in disease status in children with NS.Methods
Eight children (age range: 2-10?years) with active NS (ANS group) were enrolled. In five of these (ANS* subgroup), impedance was also measured at remission (NSR group). Thirty-eight healthy children (age range: 2-10?years) were included as healthy controls (HC group). Whole-body impedance was measured with a bioimpedance spectroscopy device (Xitron 4200) with surface electrodes placed on the wrist and ankle.Results
Values of PA, BIVA and IR were found to be significantly lower (p-value range?ConclusionThe studied parameters can be used to assess change in disease status in NS patients. Data were consistent with NS being associated with expansion of ECW.
SUBMITTER: Brantlov S
PROVIDER: S-EPMC6704501 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Brantlov Steven S Jødal Lars L Andersen René Frydensbjerg RF Lange Aksel A Lange Aksel A Rittig Søren S Ward Leigh C LC
BMC nephrology 20190822 1
<h4>Background</h4>Oedema, characterized by accumulation of extracellular water (ECW), is one of the major clinical manifestations in children suffering from nephrotic syndrome (NS). The lack of a simple, inexpensive and harmless method for assessing ECW may be solved by the use of the bioelectrical impedance analysis (BIA) technique. The aims of this study were to examine whether phase angle (PA), bioelectrical impedance vector analysis (BIVA) and the impedance ratio (IR) reflect change in dise ...[more]