Ontology highlight
ABSTRACT:
SUBMITTER: Lam KG
PROVIDER: S-EPMC6707301 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Lam Kwan-Wood Gabriel KG Brick Kevin K Cheng Gang G Pratto Florencia F Camerini-Otero R Daniel RD
Nature communications 20190823 1
Meiosis is the specialized cell division during which parental genomes recombine to create genotypically unique gametes. Despite its importance, mammalian meiosis cannot be studied in vitro, greatly limiting mechanistic studies. In vivo, meiocytes progress asynchronously through meiosis and therefore the study of specific stages of meiosis is a challenge. Here, we describe a method for isolating pure sub-populations of nuclei that allows for detailed study of meiotic substages. Interrogating the ...[more]