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Association between educational level and total and cause-specific mortality: a pooled analysis of over 694 000 individuals in the Asia Cohort Consortium.


ABSTRACT:

Objective

To study the association of educational level and risk of death from all causes, cardiovascular disease (CVD) and cancer among Asian populations.

Design

A pooled analysis of 15 population-based cohort studies.

Setting and participants

694?434 Asian individuals from 15 prospective cohorts within the Asia Cohort Consortium.

Interventions

None.

Main outcome measures

HRs and 95% CIs for all-cause mortality, as well as for CVD-specific mortality and cancer-specific mortality.

Results

A total of 694?434 participants (mean age at baseline=53.2 years) were included in the analysis. During a mean follow-up period of 12.5 years, 103?023 deaths were observed, among which 33?939 were due to cancer and 34?645 were due to CVD. Higher educational levels were significantly associated with lower risk of death from all causes compared with a low educational level (?primary education); HRs and 95% CIs for secondary education, trade/technical education and ?university education were 0.88 (0.85 to 0.92), 0.81 (0.73 to 0.90) and 0.71 (0.63 to 0.80), respectively (ptrend=0.002). Similarly, HRs (95% CIs) were 0.93 (0.89 to 0.97), 0.86 (0.78 to 0.94) and 0.81 (0.73 to 0.89) for cancer death, and 0.88 (0.83 to 0.93), 0.77 (0.66 to 0.91) and 0.67 (0.58 to 0.77) for CVD death with increasing levels of education (both ptrend <0.01). The pattern of the association among East Asians and South Asians was similar compared with ?primary education; HR (95%?CI) for all-cause mortality associated with ?university education was 0.72 (0.63 to 0.81) among 539?724 East Asians (Chinese, Japanese and Korean) and 0.61 (0.54 to 0.69) among 154?710 South Asians (Indians and Bangladeshis).

Conclusion

Higher educational level was associated with substantially lower risk of death among Asian populations.

SUBMITTER: Yang K 

PROVIDER: S-EPMC6707688 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Publications

Association between educational level and total and cause-specific mortality: a pooled analysis of over 694 000 individuals in the Asia Cohort Consortium.

Yang Keming K   Zhang Ying Y   Saito Eiko E   Rahman Md Shafiur MS   Gupta Prakash Chandra PC   Sawada Norie N   Tamakoshi Akiko A   Gao Yu-Tang YT   Koh Woon-Puay WP   Shu Xiao-Ou XO   Tsuji Ichiro I   Sadakane Atsuko A   Nagata Chisato C   You San-Lin SL   Yuan Jian-Min JM   Shin Myung-Hee MH   Chen Yu Y   Pan Wen-Harn WH   Pednekar Mangesh S MS   Tsugane Shoichiro S   Cai Hui H   Xiang Yong-Bing YB   Ozasa Kotaro K   Tomata Yasutake Y   Kanemura Seiki S   Sugawara Yumi Y   Wada Keiko K   Wang Renwei R   Ahn Yoon-Ok YO   Yoo Keun-Young KY   Ahsan Habibul H   Chia Kee Seng KS   Boffetta Paolo P   Kang Daehee D   Potter John D JD   Inoue Manami M   Zheng Wei W   Nan Hongmei H  

BMJ open 20190822 8


<h4>Objective</h4>To study the association of educational level and risk of death from all causes, cardiovascular disease (CVD) and cancer among Asian populations.<h4>Design</h4>A pooled analysis of 15 population-based cohort studies.<h4>Setting and participants</h4>694 434 Asian individuals from 15 prospective cohorts within the Asia Cohort Consortium.<h4>Interventions</h4>None.<h4>Main outcome measures</h4>HRs and 95% CIs for all-cause mortality, as well as for CVD-specific mortality and cance  ...[more]

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