IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease.
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ABSTRACT:
SUBMITTER: Hojen JF
PROVIDER: S-EPMC6707854 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease.
Højen Jesper Falkesgaard JF Kristensen Marie Louise Vindvad MLV McKee Amy S AS Wade Megan Taylor MT Azam Tania T Lunding Lars P LP de Graaf Dennis M DM Swartzwelter Benjamin J BJ Wegmann Michael M Tolstrup Martin M Beckman Karsten K Fujita Mayumi M Fischer Stephan S Dinarello Charles A CA
Nature immunology 20190819 9
Interleukin (IL)-1R3 is the co-receptor in three signaling pathways that involve six cytokines of the IL-1 family (IL-1α, IL-1β, IL-33, IL-36α, IL-36β and IL-36γ). In many diseases, multiple cytokines contribute to disease pathogenesis. For example, in asthma, both IL-33 and IL-1 are of major importance, as are IL-36 and IL-1 in psoriasis. We developed a blocking monoclonal antibody (mAb) to human IL-1R3 (MAB-hR3) and demonstrate here that this antibody specifically inhibits signaling via IL-1, ...[more]
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