Ontology highlight
ABSTRACT:
SUBMITTER: Tsai TY
PROVIDER: S-EPMC6708378 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Tsai Tony Y-C TY Collins Sean R SR Chan Caleb K CK Hadjitheodorou Amalia A Lam Pui-Ying PY Lou Sunny S SS Yang Hee Won HW Jorgensen Julianne J Ellett Felix F Irimia Daniel D Davidson Michael W MW Fischer Robert S RS Huttenlocher Anna A Meyer Tobias T Ferrell James E JE Theriot Julie A JA
Developmental cell 20190401 2
Efficient chemotaxis requires rapid coordination between different parts of the cell in response to changing directional cues. Here, we investigate the mechanism of front-rear coordination in chemotactic neutrophils. We find that changes in the protrusion rate at the cell front are instantaneously coupled to changes in retraction at the cell rear, while myosin II accumulation at the rear exhibits a reproducible 9-15-s lag. In turning cells, myosin II exhibits dynamic side-to-side relocalization ...[more]