Metabolic engineering of roseoflavin-overproducing microorganisms.
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ABSTRACT:
SUBMITTER: Mora-Lugo R
PROVIDER: S-EPMC6709556 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Metabolic engineering of roseoflavin-overproducing microorganisms.
Mora-Lugo Rodrigo R Stegmüller Julian J Mack Matthias M
Microbial cell factories 20190826 1
<h4>Background</h4>Roseoflavin, a promising broad-spectrum antibiotic, is naturally produced by the bacteria Streptomyces davaonensis and Streptomyces cinnabarinus. The key enzymes responsible for roseoflavin biosynthesis and the corresponding genes were recently identified. In this study we aimed to enhance roseoflavin production in S. davaonensis and to synthesize roseoflavin in the heterologous hosts Bacillus subtilis and Corynebacterium glutamicum by (over)expression of the roseoflavin biosy ...[more]
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