Ontology highlight
ABSTRACT:
SUBMITTER: Acton D
PROVIDER: S-EPMC6709688 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Acton David D Ren Xiangyu X Di Costanzo Stefania S Dalet Antoine A Bourane Steeve S Bertocchi Ilaria I Eva Carola C Goulding Martyn M
Cell reports 20190701 3
Acute itch can be generated by either chemical or mechanical stimuli, which activate separate pathways in the periphery and spinal cord. While substantial progress has been made in mapping the transmission pathway for chemical itch, the central pathway for mechanical itch remains obscure. Using complementary genetic and pharmacological manipulations, we show that excitatory neurons marked by the expression of the neuropeptide Y1 receptor (Y1<sup>Cre</sup> neurons) form an essential pathway in th ...[more]