Ontology highlight
ABSTRACT:
SUBMITTER: Jameei A
PROVIDER: S-EPMC6709731 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Jameei Aida A Nagarajan Deepesh D Sarikhani Mohsen M Chandra Nagasuma N Karande Anjali A AA
Monoclonal antibodies in immunodiagnosis and immunotherapy 20190715 4
Tumor necrosis factor-α (TNFα), one of the major proinflammatory cytokines, plays a key role in an effective immune response. However, the chronic presence of TNFα can lead to several inflammatory disorders, such as rheumatoid arthritis, psoriasis, Crohn's disease, etc. Inhibition of TNFα by pharmacological inhibitors or antibodies has proven to be effective in palliative treatment to some extent. The aim of this study was to develop an anti-TNFα antibody, which may be used as a therapeutic opti ...[more]