Ontology highlight
ABSTRACT:
SUBMITTER: Tirier SM
PROVIDER: S-EPMC6710272 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Scientific reports 20190826 1
Patient-derived 3D cell culture systems are currently advancing cancer research since they potentiate the molecular analysis of tissue-like properties and drug response under well-defined conditions. However, our understanding of the relationship between the heterogeneity of morphological phenotypes and the underlying transcriptome is still limited. To address this issue, we here introduce "pheno-seq" to directly link visual features of 3D cell culture systems with profiling their transcriptome. ...[more]